Sentence examples for profiling of compounds from inspiring English sources

Such profiling of compounds based on physicochemical descriptors has been in use since the late 1990's and many excellent research articles on this concept exist [23 34].

These results suggest that the time-lapse imaging system to determine the timing of each event in individual cells can provide a novel insight into features of a cell mass by single-cell analysis and is expected to be utilized for profiling of compounds that can serve as candidate drugs.

Experimentally, promiscuity can be studied by profiling of compounds on arrays of targets.

Two fundamental methods to search for novel natural products from extracts are: bioassay-guided fractionation and chemical profiling of compounds possessing unique structural novelty.

In vitro profiling of compounds promises to provide information on molecular mechanisms of toxicity, and may allow the creation of algorithms for predictive in vivo toxicology.

Experimentally, promiscuity can be assessed by profiling of compounds or drugs on arrays of biological targets, although such studies might often only provide an incomplete picture of in vivo effects.

Finally, further profiling of compound 7 is presented, including demonstration of enhanced glucose tolerance in an in vivo mouse model.

Profiling of compound 3 in our panel of assays demonstrated that it was more potent than compound 2 in each of the assays, with a particular improvement in rDAAO inhibition (Table 1).

This work highlights the power of combining multiple approaches, including large-scale cancer cell line sensitivity profiling and unbiased genomic profiling of compound-resistant clones, to reveal the mechanisms of action or the molecular targets of small-molecule probes.

PK profiling of compound 17 revealed that it possessed a half-life of 2 h and good oral bioavailability in mouse (Fig. 4), although it displayed moderate to high clearance.

Meanwhile the potent activity profile of compounds 5 was discovered.