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Further RISC and GW/P body RNA component profiling is required.
Impurity profiling is required as part of the registration process by many regulatory authorities, including the FDA and the European Union′s Committee for Medicinal Products for Human Use (CHMP).
We did not find a correlation between the methylation profile of RCC cells lines and response to epigenetic therapy but it could be that more comprehensive methylation profiling is required to uncover such an effect.
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The current work clearly demonstrates that both global ChIP assays and global expression profiling are required to understand the gene regulatory network governed by a transcription factor.
To identify novel factors influencing sugar accumulation in tubers, unbiased and comprehensive approaches such as transcriptome and proteome profiling are required.
24 Further studies, including gene expression profiling, are required to confirm these results and to identify the cell of origin in PIOL lesions.
In order to test such a hypothesis, adequately powered RCTs with placebo-controlled-phases of sufficient duration and comprehensive baseline cardiovascular risk factor profiling are required, to evaluate the possible effect of ustekinumab and briakinumab on human atherogenic plaque.
Domestic hot water (DHW) profile is required to estimate energy use and system design.
Information about whole soil profiles is required in the assessment of present vegetation distribution and future response to climate change.
For the accurate assessment of fatigue lifetimes a detailed knowledge of the residual stress profile is required.
In order to control the degree of stratification, understanding of flow pattern and temperature profiles is required.
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