Kinase profiling and structure-based drug design guided the optimization from the initial 1,2,3-benzotriazole hit to a potent and selective JNK inhibitor, compound 24f (JNK1 and 2 IC50 = 16 and 66 nM, respectively), with bioavailability in rats and suitable for further in vivo pharmacological evaluation.
Through the constraints of the structural information, an outcome with correct network profiles and structure can be obtained.
Simultaneous GPS observations from about 150 stations of European Permanent Network (EPN) have been used for studying dynamics of latitudinal profiles and structure of mid-latitude ionospheric trough (MIT).
With our nation's recent history of economic complexity, it has become more and more common to see changes to the tax profile and structure of many taxpayers' lives and tax returns.
CNFpred combines sequence information (a sequence profile) and structure information using a probabilistic non-linear scoring function and is superior to current methods in several respects.
Quantitative indicators reveal insights about the particular profiles and structures; however, when presented with the network visualizations (Figures 4, 5, and 6), the structures become explicit and actionable.
We must elucidate the transcriptional and epigenetic profiles and structures of a gene cluster to understand the mechanisms by which imprinted expression is regulated.
In SNPs3D, the classification into in vivo functional impact categories of the SNP was based on two Support Vector Machine (SVM) models: protein sequence conservation profiling and protein structure stability.
The paper presents a design exercise of upgrading a typical rock armoured revetment by modifying the structure profile and adding structure elements.
Such inhibitors were obtained through interdisciplinary research, involving structure-based ligand design based on alanine-scanning mutagenesis, thermodynamic profiling, and cocrystal structures with the gp120 core, in conjunction with synthesis and detailed biological evaluation.
The theory does not posit universal linguistic categories or structures for language; rather it provides a road map for identifying, describing and profiling categories and structures of particular languages, or any number of languages, in a systematic manner.
