Sentence examples for profiles of module from inspiring English sources
Like for module 29 and SRF, the expression profile of TCF12 is highly divergent from the expression profiles of module 18 genes, explaining why this gene was not selected as module gene or regulator (data not shown).
It was hypothesized that gene expression profiles of modules were up- or down-regulated in a manner that contributed to the muscling phenotype of the sire group.
The distinct expression profiles of modules are represented by the module eigengene (Langfelder and Horvath 2007), which correspond to the first principal component of the module expression matrix and which can be regarded as a representative for the gene expression in a module.
We demonstrate that our method can address this challenge by decomposing the reverse engineering problem into modules, where two steps are involved: the gene expression data is clustered into modules with biological significances to reduce the problem dimensionality, and the network is built based on the expression profiles of modules.
Expression profile of Module Eigengenes.
The decrease in the relative abundance of B cells and MHC II reported by Rubins et al [ 1] are corroborated by the profile of module Antigen processing and presentation.
To ensure the eigengene sufficiently represented the expression profiles of the module genes, modules for which the first principle component explained less than 50% of the variation were excluded from the network.
To define a representative module expression profile (referred to as the module eigengene), we summarized the (standardized) gene expression profiles of the module eigengene (= first principal component).
To define a representative module expression profile (referred to as the module eigengene), we summarized the (standardized) gene expression profiles of the module by their first principal component.
Figure 3 shows the expression profiles of the module eigengenes for the four identified WGCNA modules for each sire group.
We also drew the activity profile of each expression module, which is defined as the mean values of the expression profiles of the module genes: the heat map in Figure 8 shows in which tissues each expression module is up or down-regulated.
