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You don't have to look at profiles in isolation, either.
Our findings suggest that correlation of expression profiles, in isolation, is not a suitable basis for the analysis of relationships between cis-eQTLs.
Motivation: Tissue heterogeneity, arising from multiple cell types, is a major confounding factor in experiments that focus on studying cell types, e.g. their expression profiles, in isolation.
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For example, comparisons between pitavastatin and atorvastatin [11, 12, 30], pravastatin [31], rosuvastatin [31] and simvastatin [32] have shown that these statins have similarly low treatment emergent adverse event profiles when administered in isolation.
More generally, they make clear that great caution must be used when interpreting ChIP enrichment profiles for individual factors in isolation, as they will include factor-specific as well as collective contributions.
The chemical reactivity profiles obtained by probing individual regions of the 3′UTR in isolation match the profiles of those regions in the context of the intact 3′UTR.
Marguet and colleagues concluded that "chronic cough is not associated with the cell profiles suggestive of asthma and in isolation should not be treated with prophylactic anti-asthma drugs" [ 70].
This limitation is not a problem because the profile should not be used in isolation, but having in mind the formal definitions of the OBO Relation Ontology.
Friend emphasised that molecular profiling should not be viewed in isolation, but should be regarded as complimentary to, and used in parallel with, existing pathological parameters.
Because log2 ratios for the methylation-profiling array correlated very strongly with the wildly varying log2 ratios from the conventional CGH array for this sample (in isolation, each profile appeared to have large random noise), we eliminated this sample from further analysis.
A recommendation for future research may be to estimate the acceptable health curve with a larger set of complete health profiles, rather than with health problems in isolation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com