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The phases of enrolment are described in more detail in the cohort profile paper.
This paper is a response to a critique of the author's previous high profile paper in Nature [ 1].
The phases of enrolment are described in more detail in the cohort profile paper: < http://ije.oxfordjournals.org/content/early/2012/04/14/ije.dys064.full.pdf+html>.pdf+html>
However, there was a high profile paper from the McMahon lab, published two years ago in Cell, claiming that if all three epsin genes were knocked down by siRNA in HeLa, BSC1, or RPE1 cells, clathrin-mediated endocytosis was effectively abolished: the phenotype was as severe as when clathrin or AP-2 were knocked down.
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"In the last few years, our small institute [now with 17 principal investigators] is publishing at least one-third of all high profile papers in the biological sciences from China".
The importance of stochastic events and molecular chaperones in the relationship between alleles and phenotypes has been called to attention in two recent high profile papers (Burga et al., 2011; Casanueva et al., 2012).
Along the way, the authors correct findings published in several high profile papers by others and provide a refreshing interpretation of the nature of the lipid accumulation in glp-1 mutants and the role of SKN-1 in response to this lipid overload.
The company has tried several approaches, seemingly in vain, to revive the fortunes of The Independent, a left-leaning daily that is the company's highest-profile paper.
In such an environment, a high-profile paper can mean the difference between a career in science or leaving the field.
The idea is to expand the scope of the work that got Riley into the headlines last year after a high-profile paper published in the journal Nature in which he showed a means of repairing cells damaged during a heart attack in mice.
"We don't really care if they've had a high-profile paper," Ramakrishnan says.
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