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An important characteristic of an altered peptide ligand is its ability to alter the cytokine profile of responding T cells.
TCR interaction with APLs was found to alter the extent of antigen-specific T cell activation by skewing the cytokine profile of responding T cells or by anergy induction [ 25].
Responses to intermediate ambiguous cues resulted in a similar profile of responding to that seen in rodents and, in each study, the participant's judgement bias scores correlated with questionnaire measures of mood (Paul et al., 2011; Anderson et al., 2012; Schick et al., 2013).
Defining the mechanisms of resistance to EGFR inhibitors coupled with identifying the clinical and molecular profile of responding vs nonresponding patients in ongoing trials remains an important priority and should hopefully enable a more focused use of these drugs in future.
We have recently piloted an operant judgement bias task which uses only reward-based outcomes (similar to the spatial judgement bias task discussed above (Brydges et al., 2011; Chaby et al., 2013) and found that the profile of responding to ambiguous cues is not the same as studies using the reward versus punishment avoidance approach.
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We also examined the profile of persons responding "don't know" compared to other non-responders.
The screening of ~800 miRNA transcripts using NanoString profiling resulted in a minimal number of responding targets.
In the present study, particular attention was focused on the detailed temporal profiling of miRNAs responding to developmental stage transitions of silkworms.
Responsiveness of genes to perturbations is a dynamic property that was never studied systematically because such studies require the analysis of expression profiles of cells responding to a large variety of disturbances, and such databases did not exist before.
To distinguish gene responses to specific factors from responsiveness in general, it is necessary to analyze gene expression profiles of cells responding to a large variety of disturbances, and such databases did not exist before.
Expression profiling of xenografts responding to treatment with GLV-1h68 based on a mouse-specific platform and hence representative of the host's response to the GLV-1h68-infected human xenograft suggested that their eradication is associated with the over-expression of signatures consistent with innate immune defense activation.
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