Due to the retrospective nature of assessments of premorbid adjustment, a prospective study examining profiles of functioning using the TUS with individuals in the prodromal phases of illness would be useful in unpicking whether functional deficits highlighted in the current study were a consequence of the onset of psychosis or whether they existed premorbidly.
There is, however, no general agreement on the exact profile of functions disturbed.
Initially, we derive an annotation profile of functions, processes, cellular and anatomical components, pathways and model organism phenotypes that may be relevant to the query human disease.
It is still unclear whether this limited scope is sufficient for identifying different profiles of functioning of frail, pre-frail and non-frail older people.
However, while comparing the abundance profiles of functions between communities, the frequencies of the functions should not be masked by the assembly, and the read depths of the contigs should be accounted for.
Most of the neurocognitive assessment batteries that have previously been used in schizophrenia studies involve detailed assessments of the entire profile of neuropsychological function, including normal functioning, but require lengthy and complex procedures.
As a next step, this MURF1 profile HMM is searched against all profile HMMs of function-known proteins available from the public databases Pfam, PANTHER, SMART, COG, PDB and SCOP.
This pattern resembles the previously reported expression profile of C-function genes in Petunia and Antirhinnum, suggesting a shared C-function between AG and SHP orthologs [ 31].
The behavioral profile of NPY function has been extensively studied using traditional pharmacological and classic genetic animal models.
