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Therefore, monitoring the profile of alteration of TCR repertoire will provide a proof of indirect recognition of MHC molecules through TCR restriction.
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After the first transplantation, the molecular profile of alterations remained constant.
Development of highly parallel technologies now allows investigation of a global profile of alterations in DR on the level of gene sequence, expression, protein alterations, and other molecular levels.
A microarray profile of alterations in gene expression associated with a single compound represents a unique signature that can be used to detect compounds with endocrine-disrupting activity in the environment.
The findings of this study indicated that AIS was associated with an abnormal bone quality profile suggestive of alteration in endocortical modeling, derangement in trabecular bone structure and disturbance in bone mineralization.
Genes were assigned to the networks according to drug-induced profiles of alterations in expression (Additional files 1 and 5).
In the present study, we performed global profiling of alterations in DNA as well as expression of mRNA and miRNA in tumors and their matched normal tissues from 30 ESCC cases.
Previous work focusing on measurement of personality change in Alzheimer's disease has shown a qualitatively similar although less marked profile of personality alteration, with increased neuroticism and decreased conscientiousness, openness and extraversion.
Considering the promastigotes whose flagellum/body length ratio was ≥2, the profile of size alteration detected by morphometric analysis was similar among isolates, showing an increase of the percentage of small parasite forms (metacyclic forms) at 6th or 10th day of culture.
The impact of signalling-pathway alterations in RMS was recently reinforced in a genome-wide study, which characterised the profile of somatic alterations in 147 RMS tumour samples.
As a benchmark we show a profile of genomic alterations in glioblastomas in Figure 2A.
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