According to a retrospective article by GamesRadar in 2009, "while it didn't innovate much in the gameplay department, Darkwatch was a solid shooter with proficient controls.
Concentration of peripheral blood lymphocyte subsets in IL-15-deficient and IL-15-proficient, control and vaccinated NeuT mice.
Strikingly, the polycomb repressor EZH2 is also higher expressed in BRCA1-deficient tumors than in BRCA1-proficient control tumors.
Spleen cell yield and splenocyte subset yield of IL-15-deficient and IL-15-proficient, control and vaccinated, NeuT mice.
Synergistic cytotoxicity of olaparib and cisplatin was also seen against BRCA2-deficient cells but not against BRCA2-proficient control cells (Evers et al, 2008).
Interestingly, although EZH2 levels were also reduced to a similar level in the BRCA1-proficient control cells, these cells seem much less affected by EZH2 loss.
After comparing gene expression patterns of BRCA1-deficient mouse mammary tumors with BRCA1-proficient control tumors, we noted that Ezh2 expression was particularly high in BRCA1-deficient tumors.
Concentration of peripheral blood leukocytes, lymphocytes and granulocytes in IL-15-deficient and IL-15-proficient, control and vaccinated NeuT mice.
Next, we employed our established siRNA-based approach using isogenic RAD54B-proficient (control) and RAD54B-deficient HCT116 cells (McManus et al. 2009) to validate the RAD54B SLD1 SL interaction.
To analyze syntenic genomic regions for overlapping CNAs, we applied two statistical frameworks to BRCA1-deficient, BRCA2-deficient and BRCA1/2-proficient control mouse and human breast cancers: a total of six tumor groups.
Importantly, our mouse model allows us to compare BRCA1-deficient mammary tumors (arising in K14cre Brca1 F / F ;p53 F / F (KB1P) mice) with BRCA1-proficient control tumors (arising in K14cre Brca1 w. t / w. t ;p53 F / F (KP) mice).
