Hence, the more proficient an antiangiogenic agent is, the more efficiently it will cause hypoxia and unlike normal cells, tumor cells are much better equipped to cope with hypoxia.
The finding of novel pharmacologic agents proficient to improve adiponectin plasma levels should be target of exhaustive research.
Since adiponectin levels are consistently inversely correlated with each of these ailments, the finding of pharmacologic agents proficient to improve its plasma levels should be target of exhaustive research.
Based on laboratory and epidemiological evidences it can be concluded that routine consumption/application of these natural agents may provide proficient safeguard against damaging effects of solar ultraviolet radiation as well as other skin carcinogens present in environment.
As an insurance agent I had been proficient and tidy in filling out the forms but less good in tipping the customers into the plunge that would bring a commission.
For example, cells deficient for the repair protein O-methylguanine-DNA methyltransferase (MGMT), which are much more sensitive than MGMT proficient cells to O-methylguanine generating agents, show dose-dependently decrease in the Bcl-2 expression level (Ochs and Kaina, 2000).
MIC and FIC results indicated that the combination of the above two natural compounds was proficient in lowering the MICs of individual agents.
Thus researchers are trying to find out proficient approaches, including the discovery of novel chemotherapeutic agents for the possible management and treatment of infected patients.
The progression in the structural biology of the viral envelope prompted the discovery of novel targets, which can be demonstrated a proficient approach for drug design of anti-retroviral agents.
Further support for mismatch repair being involved in sensitivity of the minor groove alkylators is that two cisplatin-resistant sublines of the human ovarian adenocarcinoma cell line A2780 (A2780/CP70 and A2780/MCP-1) are defective in hMLH1 expression and are more resistant to these agents than the parental mismatch repair proficient cells.
