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In the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study, 20,332 patients with recent ischemic stroke were randomized to receive either 80 mg telmisartan (n = 10,146) or placebo (n = 10,186) (25).
101 The ProFESS study 16 compared telmisartan 80 mg daily (n = 10,146) with placebo (n = 10,186) initiated early after an ischemic stroke, less than 90 days before randomization.
Indeed, the average initial BP levels in these studies were 142/8 2mmHg in ONTARGET, 144/84 mmHg in the PRoFESS study, and 141/82 in the TRANSCEND study.
Recently, the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) study compared the effects of low-dose aspirin (ASA), combined with extended-release DIP (25 mg and 200 mg, respectively; twice daily), with the effects of clopidogrel (75 mg/d) on the secondary prevention of stroke [ 4].
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