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Then under the optimal conditions (2.0 mL glycol and 120°C),several aldehydes were separately reacted with various enaminones and malononitrile to obtain different products (Scheme 6).
Clˉ, Brˉ, NO3ˉ, SO42ˉ, ClO4ˉ and AcOˉ in order to determine the effect of the anions on the formed products (Scheme 3).
Initial studies show PFCP aryl ether polymers react with dinucleophiles, undergo cross-linking in different reaction conditions and give insoluble products (Scheme 8).
In the present study, we have established that reaction of acetylpyrazole 1 with N-thiosemicarbazide 16 and aryl carbohydrazonoyl chlorides 3d, g gave the respective 1,3,4-thiadiazoles 23a, b as the end products (Scheme 5; Table 1).
Here, attack on PFCA ring by phenoxide ion, resulted in situ due to action of base on bisphenol, generates a carbanion on perfluorocycloalkene ring which, theoretically, can eliminate fluoride ion resulting in allyl and vinyl substituted products (Scheme 3).
Chloride ion of compounds (9 11) and (13) was replaced with one equivalent of morpholine at 70 80 °C in a dioxane/water solvent mixture using sodium carbonate as a base by the conventional method, or by using microwave irradiation, employing a multimode reactor (Synthos 3000, Aton Paar GmbH, 1400 W maximum magnetron) to give the corresponding products (Scheme 2).
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It has also been shown that nucleophiles such as DTT, hydroxylamine, and sodium 2-mercaptoethanesulfonate (MESNA) can intercept the (thio ester intermediates (linear and branched), resulting in the formation of N-terminal cleavage products (Schemes 1 and 2, step ii).
They are associated with a tensor-product scheme and an acceptance-rejection criterion.
Open innovation requires the support from the product scheme or architecture to allocate the product function to its physical components.
The I-HAVE-PRODUCT scheme is very simple and was explained by an example in Fig. 3.
Compound 5 and 10 were found to be a mixture of two products, a) dicoumarol compound and b) translactonized product (Scheme 1).
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