Sentence examples for productive orientation from inspiring English sources

The resultant productive orientation was retained for the remainder of the simulation.

In particular, PTEN associates with the bilayer in a nonproductive orientation, but the initial encounter was followed by rotational reorientation to move PTEN in a productive orientation.

The productive orientation of PTEN on the membrane has been suggested to involve association of the C2 domain loops with the lipids.

It is likely that these substituents are too bulky for a productive orientation of the substrate in the active site of the enzyme.

In OYE1, binding of carvone in a catalytically productive orientation (Cβ near N5) is facilitated by hydrogen bonding of its carbonyl group with H191 and N194.

PTEN continued to interact with the bilayer in the productive orientation described for the CG-MD simulations with the C2 domain loops penetrating into the bilayer.

Upon binding of the streptogramins, the peptidyl transferase centre undergoes a significant conformational transition, which leads to a stable, non-productive orientation of the universally conserved U2585.

Therefore, when Y is mutated to phenylalanine, the absence of phosphorylation at this residue would be predicted to fix the αC helix in the kinked non-productive orientation, stabilizing the kinase in the inactive state.

In sum, cooperative scenarios mainly pertain to regulative effects on substrate ingress, tuning of the open/closed equilibrium of the substrate access channel, modulation of the active-site capacity and productive ligand orientation toward the iron-oxene core.

On the basis of these simulations, we engineered CYP3A4 mutants I369F, I369L, A370V, and A370L, in which the productive binding orientation was expected to be stabilized, thus leading to increased turnover of CBZ to the 10,11-epoxide product.

However, the relative contributions of the N-terminal α-helix and the rest of the protein in membrane binding of PLA2 and its productive-mode orientation at the membrane surface are not well understood.