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Alteration of the normal process results in the production of altered mRNA or in an off-balance production of tissue-specific mRNA isoforms [ 49- 51].
Thus, as is the case in animals [ 37, 38], this mode of APA may contribute to a proliferation of species-specific variability in gene expression (through the production of altered mRNA and protein isoforms).
The results confirm predictions, and show that highly specific changes in the modular polyketide synthase genes, akin to strategies used in the laboratory to engineer production of altered polyketide antibiotics, account for the differences.
In cartilage, the down-regulation of COL3A1 and up-regulation of COL6A1 and HAPLN1, proteins involved in ECM structure and chondrocyte microenvironment and micromechanical regulation [ 30] suggest a production of altered ECM.
Viral DNA integration rearranges both host and viral genes, leading to the production of altered protein products and making hepatocytes more susceptible to HCC [ 165].
As viral DNA integration rearranges both host and viral genes leading to the production of altered protein products making hepatocytes more susceptible [ 17].
Similar(52)
Similarly, Tabata explained that he and the staff were very wary throughout production of altering the "fans' perception of Final Fantasy VII's iconic characters".
After establishing a base case for cellulose hydrolysis by implementing kinetic values obtained from the literature, we examined the effect on rates of degradation and saccharide production of altering key enzyme parameters.
At Yale, he devised a process that allows mass production of genetically altered mice, an important step toward decoding the genome.
The function of the mucociliary transport system is impaired against the background of increased production of pathologically altered mucus.
Here, decalcification and soil formation processes (such as the in-situ production of Fe) altered the geochemical fingerprint of the original deposit (cf. Szczucinski, 2012).
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