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Developments over the past nearly 30 years have also established T. reesei as an incredibly useful host for large-scale protein production, largely based on the regulatory elements of the gene encoding the most abundant secreted cellulase component, cellobiohydrolase I (CEL7A) [ 8, 9].
Prescription acne medication is another example of a product that is priced exorbitantly relative to the costs of production, largely because of the way medications are prescribed, purchased, and paid for today.
"One Slight Hitch" has a cutesy, slightly saccharine ending, but Mr. Grifasi's lively production largely makes up for it.
The production, largely from and by the Oberlin Conservatory of music, is small in square footage but hugely complex in its video and sound collages.
Herat has long been a center for burka production, largely because it has a cheap labor and fairly consistent access to electrical power.
Electronic gadgets typically get updated every six months, while new car models stay in production, largely unchanged, for four or five years at a time.
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Certainly Ms. Ananiashvili has overhauled its repertory, with 21 new productions, largely of Western ballets.
The last of these, he says, remains "the favourite of all my productions" – largely because its success vindicated his bloody-minded instincts.
But the question it urgently raises is when will Trevor Nunn, whose own productions largely sustain the National, surround himself with a directorial team capable of working to his level.
The sharp rise in US oil production is largely thanks to shale oil, a product many have hailed as the saviour of the US energy market.
Protease inhibitors are produced by a large number of cyanobacterial genera and their motive and mode of production are largely unknown.
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