This elicits disproportionate production of Treg cells and shifts the cellular balance from effector helper cells towards cells with suppressor function in order to avoid immune system mediated destruction.
This may be a reflection of disproportionate production of miR-218 from each genomic site, alterations in miRNA biogenesis or miR-218 may have a promoter separate from its host gene.
Fluctuations on the supply side of cereal production have a disproportionate impact on prices because of the relatively small short-term price elasticity of demand for cereals in the aggregate.
Given that the Swedish mutation in the transgene human APP drives β-cleavage and sAPPβ production [41], [42], the disproportionate levels of sAPPβ in the Tg2576 mice may impact the turnover of the relatively underrepresented sAPPα.
The production of propylene requires a disproportionate share of the hydrogen and co-products such as propane, and dry gas requires an even greater share of hydrogen.
The production of propylene requires a disproportionate share of the hydrogen and co-products, including propane, and dry gas requires an even greater share of hydrogen.
But its production uses up a hugely disproportionate share of agricultural resources.
These include: poor workstation and workplace designs, unbalanced workload, complicated operational processes, unsafe conditions, faulty maintenance, disproportionate attention to production, ineffective training, non-responsive managerial systems, poor planning, lax oversight and inadequate enforcement of safety regulations, and an overall weak organizational safety culture.
Specifically, there is strong evidence suggesting that a disproportionate and persistent production of cytokines can significantly increase the risk and extent of brain injury [ 5, 24].
The severity of DENV infection seems to be due more to disproportionate inflammatory cytokine production than to direct viral effects [ 28- 30].
