We define a new term "patholog" to mean a homolog of a human disease-related gene encoding a product (transcript, anti-sense or protein) potentially relevant to disease.
We defined "patholog" as a non-human gene with homology to a human gene that encodes a product (transcript, anti-sense or proteins) involved in human disease.
For ZDHHC16, two primers sets were also created, with the first set producing a 97-bp product (transcript that excludes the exon) and the second set producing a 118-bp product that included the skipped exon.
If the remnant introns (introns a and b) that flank the newly formed large exon (exon 2) happen to be small, the splicing sites of intron a as well as b will be recognized by means of intron definition [ 37, 39] and normal mRNA product (transcript B) will therefore be synthesized.
GeneDistiller includes the following data: Genes, gene positions, gene RIFs, gene ontology, cellular localisation of gene products, transcripts, exons, OMIM reports, mouse phenotypes, protein-protein interactions, gene expression data, protein domains, SNP markers, STR markers.
IKB contains about 40,000 nodes representing mammalian genes and their products (transcripts, proteins, miRNAs, second messengers, etc).
The BAM file from each library was analysed with the BEDTools [ 44] software package, which provided counts of reads mapping to different gene products (transcripts) that were represented in the annotation file (GTF).
Functional genomic analysis involves a systematic effort to understand the function of genes and gene products (transcripts and proteins) and their role in biological systems (cells, tissues and organisms), until now classically performed for single genes (e.g. generation of mutants, analysis of proteins and transcripts), in the context of the whole genome.
Only truncated mRNA products (transcript A) are synthesized.
