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Open innovation requires the support from the product scheme or architecture to allocate the product function to its physical components.
Compound 5 and 10 were found to be a mixture of two products, a) dicoumarol compound and b) translactonized product (Scheme 1).
The amide product could be easily separated from the ester formed as a minor product (Scheme 1) inspite of similarity in molecular weight, structure and adsorption properties.
The product was recovered by filtration, washed with alcohol and then was dried in oven under vacuum at 40°C for 48 h to give a yellowish amorphous product (Scheme 1).
As described above, bromoacetic acid and methanol would be produced as the by-products during the enzymatic synthesis of the desired product (Scheme 1), which may have a detrimental effect on the enzyme stability.
It resolves the tough problem of consistently maintaining a product scheme to prevent defects arising from inconsistent general design data or incorrect versions of the layout scheme existing within the schemes of downstream design.
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And analysis of the current product schemes shows this design method is valid.
How to collaboratively compute the correct scalar product result without leaking any participantsʼ private information becomes the primary principle of designing secure scalar product schemes.
They are associated with a tensor-product scheme and an acceptance-rejection criterion.
The I-HAVE-PRODUCT scheme is very simple and was explained by an example in Fig. 3.
Then under the optimal conditions (2.0 mL glycol and 120°C),several aldehydes were separately reacted with various enaminones and malononitrile to obtain different products (Scheme 6).
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