Sentence examples for product dissolution from inspiring English sources

Simulated gastrointestinal media have been developed covering fasted and fed states to facilitate in vitro prediction of gut solubility and product dissolution.

In previous studies [9, 10], it was shown that a gel polymer membrane can act as a physical barrier, controlling the cathode reaction product dissolution, restricting their diffusion from the cathode, and thus preventing their reaction at the anode side.

The giBCS model for orally administered drugs provides a basis for correlating in vitro drug product dissolution to in vivo bioavailability assuming that drug dissolution, drug dose, and GI permeability are the attributes dictating the rate and extent of drug absorption via the oral route of administration (USDHHS/FDA 2015).

In addition, the BCS also takes into account the drug product dissolution which can be either rapid or slow.

For example, if an oral product was developed to be locally acting and is designed to be intact until at least pH 6.8 or greater (reaches the distal GI tract) and then a burst of drug (greater than 80%) is released in 15 30 min after reaching the site, one could argue that this profile would be similar to that of an immediate-release product dissolution and that the f2 rules would be applicable.

Finally, the noise resistance continuously decreased as a result of corrosion products dissolution.

Table 3 Testing types and number of formulations or products tested by the Formulation WG Test Formulations Products Dissolution 64 952 Purity 13 113 Assay 2 27 Uniformity of dosage units 2 58 Composition 1 13 Total 82 1163.

When comparing the test and reference products, dissolution profiles should be compared using a similarity factor (f2).

To segregate the recombinant duplexes, the HJs must be removed, which can occur by the activity of a helicase and topoisomerase to produce only noncrossover (NCO) products (dissolution), or by endonucleolytic cleavage (resolution).

Similarly, Arami et al. [8] produced nanostructured rutile with 15 20 nm crystallite size, which is usually difficult to be obtained at low temperatures, by simply treating in ultrasonic bath the product of dissolution of TiO2 pellets in 10 M NaOH.

Based on the final desired products, the dissolution conditions can be tuned to optimize the recovery of certain products.