We conjecture that this inconclusiveness of findings is due to an equivocal conceptualization and operationalization of the key concepts – product difficulty and product difficulty incongruity.
However, the main effect of product difficulty and the interactions between the parent brand quality and fit variables have not been consistent across studies.
The existing studies mainly focus on product difficulty, i.e., the perceived difficulty level of designing and making the extension, whereas the latter refers to the difference between consumers' perceptions of the difficulty of designing and making the parent product and the difficulty in designing and making the extension product.
We specifically propose that product difficulty incongruity will negatively impact consumer evaluation of brand extensions, and this negative effect is stronger for high parent brand quality and consumers with high levels of need for cognition.
In both these cases, the primary immune modulatory component was a donor immune cell or tumor lysate, which have the drawbacks of any natural product: difficulty with the isolation, purification, and verification of the safety of products, batch to batch variability, limited supply, and complexity in determining structure property relationships of compounds.
However, the application of conventional HA powder in stabilizing contaminated soils is limited, due to high cost of final products, difficulties in synthesizing purified HA crystals.
However, there are limitations of microbial production like limited yields, concentrations and productivities, difficulties in the product recovery from the broth, or the need of pretreatment of most of the raw substrates.
Results showed, as expected, a higher prevalence of visual, hearing, dexterity, cognitive and product interaction difficulties in the 65 80 age group.
Direct deoxygenation of 1a was attempted using a variety of standard protocols: LiAlH4 and MeOTf/MeI/Me3SiCl,[ 22] DIBAL-H,[ 23] AlH3,[ 24] Ti O- i-Pr 4 i-Pr 4HS,[ 25] Cu(OTf)2 and TMDS; 18i in each case PMHS,[onversions (<10%) and product separation difficulties were encountered.
A company 10-K listed all of the following problems: drop-offs in orders for key products, technical difficulties and cost overruns for new products, problems consolidating a reduced operation into a single plant, refusal of key personnel to relocate and inadequate inventory controls.
