Sentence examples for producing tolerance from inspiring English sources

Interestingly, CB2 agonists can reduce nociception in several preclinical models of pain without producing tolerance [9] or central side-effects [11].

Physicians should use hypnotic agents appropriately and be aware of the reduced potential for producing tolerance and dependence with the nonbenzodiazepine hypnotic agents.

Recent evidence shows that selective agonists of CB2 receptors reduce nociception in a variety of preclinical models without producing tolerance [11, 12] or central side-effects [13], thus suggesting that CB2 agonists may represent an attractive therapeutic target for pain.

But by rapidly depressing the central nervous system and producing tolerance, they proved addictive.

As part of the protocol, all patients were exposed to IRM prior to randomisation to CRM or CRO, potentially producing tolerance.

To produce tolerance to N/OFQ-induced hypolocomotion the peptide was administered by two i.c.v.

Besides, they are prone to produce tolerance and resistance as a consequence of their continuous use for decades.

In Wistar rats, diazepam 5 mg/kg ip twice daily produced tolerance to its anticonvulsant action in 6 days.

Moreover, this compound 5 does not produce tolerance and binds to rat μ opioid receptors with two fold affinities than morphine 1.

Progress in the development of mixed µ opioid agonist/δ opioid antagonists with low propensity to produce tolerance and physical dependence is reviewed.

Fentanyl has been shown to be a potent analgesic with a lower propensity to produce tolerance and physical dependence in the clinical setting.