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It was speculated that other factors, in addition to impulsive and inattentive symptoms, or perhaps hormones affecting children with ADHD, play important roles in producing obesity during puberty.
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Specific bacterial genomes for producing obesity-related metabolites were identified.
This highlights the many psychophysiological pathways at work in producing obesity-associated morbidity.
In animal studies, high sugar diets alone do not produce obesity, but high fat and sugar diets do.
But would obesity completely reverse if the obesigenic diet was removed and replaced by a diet that would not have produced obesity in the first place?
High-fat, high-simple-carbohydrate, low-fiber diet produces obesity in C57BL/6J mice as well as fasting blood glucose levels of greater than 240 mg/dl and blood insulin levels of greater than 150 microU/ml [20], suggesting that the C57BL/6J mouse carries a genetic predisposition to develop non-insulin-dependent (type 2) diabetes.
Lesions of the ventromedial hypothalamus produce obesity and hyperinsulinemia in rats [ 7], while complete vagotomy reverses the obesity and lowers plasma insulin [ 8].
NZO mice were exposed to a carbohydrate-free diet until the age of 18 weeks in order to produce obesity and insulin resistance without hyperglycaemia or diabetes.
Recent studies suggest that fetal exposure to organotins produce obesity in male rats by activating certain nuclear receptors (Grun et al. 2006).
In animal studies, consumption of diets high in fructose produces obesity, insulin resistance and dyslipidemia (Bezerra et al 2000, Elliott et al 2002, Havel 2005, Martinez et al 1994, Okazaki et al 1994, Storlien et al 1993).
With obesity and diabetes incidence and severity now at truly disconcerting rates, it is time to consider the possibility that implicating dietary fat as the primary cause and advocating that it be minimized has been a fundamental error, despite the large body of evidence supporting mechanisms by which high-fat diets might produce obesity.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com