Sentence examples for produces tolerance from inspiring English sources

In cases of substance abuse disorder, this same cycle produces tolerance and then withdrawal if people don't keep upping their addictive habits.

Thus, we propose that chronic drinking prevents the ability of these opioid peptides to promote receptor endocytosis and, thereby, produces tolerance to opioids by mechanisms similar to those produced by morphine.

Chronic use of midazolam, phenobarbital and ketamine produces tolerance and physical dependence.

It had been suggested that morphine produces tolerance because it does not induce rapid MOPr desensitization and that morphine tolerance occurs following subsequent, as yet unknown, adaptive changes caused by prolonged MOPr signalling (Finn & Whistler, 2001).

Alterations in the ability of cocaine to inhibit the DAT translate to behavioral shifts in cocaine effects, because intermittent cocaine administration has been shown to produce sensitization of cocaine-induced locomotion while continuous administration produces tolerance to cocaine-induced locomotion.

To produce tolerance to N/OFQ-induced hypolocomotion the peptide was administered by two i.c.v.

Besides, they are prone to produce tolerance and resistance as a consequence of their continuous use for decades.

In Wistar rats, diazepam 5 mg/kg ip twice daily produced tolerance to its anticonvulsant action in 6 days.

Interestingly, CB2 agonists can reduce nociception in several preclinical models of pain without producing tolerance [9] or central side-effects [11].

Moreover, this compound 5 does not produce tolerance and binds to rat μ opioid receptors with two fold affinities than morphine 1.

Progress in the development of mixed µ opioid agonist/δ opioid antagonists with low propensity to produce tolerance and physical dependence is reviewed.