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In this study, [18F]exendin-4 was produced with a specific activity as high as 323 MBq/nmol and an injected mass of 2 ± 1 μg/kg.
The EC protocol recommends assessment of image quality of digital mammographic systems using images produced with a specific low-contrast-detail test object (CDMAM) [28, 29], which is a costly tool not readily available in all imaging departments.
While the yields with this ligand (55%) were not quite as high as IMP485 with the MPAA-NODA ligand, the peptide could still be produced with a specific activity (60.5 GBq/μmol) that was suitable for in vivo imaging studies (Figure 4).
Using this synthetic route F-labelled exendin-4 could be produced with a specific activity of 45 GBq/μmol.
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Based on the kinetics analyses, the dealloying conditions were optimized to maximize the specific surface area, allowing a Nb electrolytic capacitor to be produced with a maximum mass-specific capacitance of 650,000 μFV g−1, about three times larger than the highest value previously reported.
The engineered S. cerevisiae expressing the isolated mutant CDT-2 (I96N/T487A) produced ethanol with a specific cellobiose consumption rate of 0.069 g/g cell/h, which was 51%and55%5% higher than those of the strains harboring wild-type CDT-1 and CDT-2 in a minimal medium with 2 g/L of acetic acid.
This protocol resulted in radioiodination of the bs-scFvs at efficiencies between 14 and 42% and produced product with a specific activity of 0.5 1.3 μCi μg−1 that was >95% pure by ITLC.
In the framework of the European CATMA project [ 10, 11], a micro-array was produced with 24576 specific gene sequence tags (GSTs).
An anti-HPA-1a version of G1Δnab was produced with highly specific variable regions (B2 7, 8).
This RNA-interference technique might someday be used in genetically modified crops produced with specific nutritional goals in mind, as interference RNA targets a specific gene.
However, this may now be feasible using P. pastoris strains with an engineered glycosylation machinery that are able to produce proteins with a specific human glycoform (Hamilton et al. 2006).
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