Sentence examples for produced tolerance from inspiring English sources

In Wistar rats, diazepam 5 mg/kg ip twice daily produced tolerance to its anticonvulsant action in 6 days.

Weekly dosing produced tolerance to nicotine's decreasing effects on vertical activity and increases (i.e., sensitization) in horizontal activity at all doses, and these effects persisted for at least 3 weeks.

However, we found that chronic voluntary ethanol consumption produced tolerance to not only DAMGO but also morphine (i.t. 20 nmol/rat, Figure S1B).

Introgression of an alien chromosome from N. africana into N. tabacum produced tolerance (an amelioration of symptoms) to Potato virus Y in N. tabacum, but did not confer the immunity exhibited by N. africana per se[ 32].

To produce tolerance to N/OFQ-induced hypolocomotion the peptide was administered by two i.c.v.

Besides, they are prone to produce tolerance and resistance as a consequence of their continuous use for decades.

Interestingly, CB2 agonists can reduce nociception in several preclinical models of pain without producing tolerance [9] or central side-effects [11].

Moreover, this compound 5 does not produce tolerance and binds to rat μ opioid receptors with two fold affinities than morphine 1.

Progress in the development of mixed µ opioid agonist/δ opioid antagonists with low propensity to produce tolerance and physical dependence is reviewed.

Physicians should use hypnotic agents appropriately and be aware of the reduced potential for producing tolerance and dependence with the nonbenzodiazepine hypnotic agents.

Fentanyl has been shown to be a potent analgesic with a lower propensity to produce tolerance and physical dependence in the clinical setting.