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At later timepoints (24 h and later), enough BNP is produced to induce the known BNP effects.
If OXPHOS in mitochondria is functional under hypoxia, ROS would be produced to induce apoptosis like NB4.
Under herbivore attack, secondary metabolites such as phenolic acids, tannins, and alkaloids are produced to induce and enhance plant defense.
However, when insufficient ROS are produced to induce acute cellular demise, cells will suffer from prolonged oxidative stress whereby the intracellular antioxidative capacity is reduced in the absence of full execution of cell death pathways.
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Clinical trials have shown the necessity of broad and highly avid humoral immune responses together with high numbers of CSP-specific TCD4+ and TCD8+ cells, especially those producing IFN-γ, to induce protection.
The former theory explains that the hemorrhage from the stapedial artery produces hematoma to induce the pressure around the first and second pharyngeal arch.
In contrast, lysates of neutrophils from Tnf−/− mice lost such activities, suggesting that neutrophils produce TNF-α TNF-αduce MHEC expression of P-selecton, E-selectinduceAMHEC and ICAM-1.
Notably, damaged β-cells are reported to produce Cxcl12 (Sdf1) to induce GLP-1 production in adjacent α-cells (Yano et al., 2007).
It is at this point that the tumour requires an 'angiogenic switch', where the tumour starts to produce factors to induce neovascularisation.
The other is a "systemic HMGB1" function mediated by HMGB1 secreted by HMGB1 producing cells to induce remote organ failure in the lungs, liver, kidneys, and other organs during hemorrhagic states.
It has been proposed that IL-4 is produced to compensate the inflammatory response induced by IFN γ.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com