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Preoperative AC produced objective clinical responses in 79% of the treated patients and clinical complete responses (cCR) in 36%.
In a phase II trial, vemurafenib produced objective responses in 53% of 132 patients with metastatic melanoma harbouring a BRAF V600E or BRAF V600K mutation [14,15].
Alisertib alone also produced objective responses in medulloblastoma and glioblastoma xenografts, including a maintained complete response (BT-46 cells) and a partial response (D456 cells) [35].
However, in clinical practice, EGFR inhibitors have produced objective responses in only a small fraction (9% to 30%) of patients with advanced NSCLC [8]– [8]].
On the other hand, the same combined therapy produced objective responses with clinical improvements in 7/9 pediatric low-grade gliomas [192].
Eribulin produced objective responses in 11.5 and 9.3% of patients in the first and second trial, respectively, and clinical benefit (which includes stable disease ≥6 months) in 17% of patients in both studies [ 49, 50].
Similar(50)
Less dramatically, the efforts working scientists put into producing objective evidence attest to the importance they attach to objectivity.
Jackson was critical of the authority for "second guessing" the politics rather than producing objective advice.
For Lewis, the problem with social awareness hashtag campaigns is that they don't produce objective and measurable economic outcomes.
"Somehow Bert got this group to work together to produce objective scientific and technical reports that come very close to policy".
"I don't think that E.N.A. is unable to produce objective, truthful stories," said Tadesse Zinaye, the agency's director, who was chosen by the government.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com