Sentence examples for produce tolerance from inspiring English sources

To produce tolerance to N/OFQ-induced hypolocomotion the peptide was administered by two i.c.v.

Besides, they are prone to produce tolerance and resistance as a consequence of their continuous use for decades.

In agreement with earlier observations in rats (Lancel and Langebartels, 2000), this finding suggests that gaboxadol may not rapidly produce tolerance toward its sleep effects.

Stanford researchers said they have identified the receptors to which opioids bind to produce tolerance to the drugs and increased sensitivity to pain.

Progress in the development of mixed µ opioid agonist/δ opioid antagonists with low propensity to produce tolerance and physical dependence is reviewed.

Fentanyl has been shown to be a potent analgesic with a lower propensity to produce tolerance and physical dependence in the clinical setting.

In Wistar rats, diazepam 5 mg/kg ip twice daily produced tolerance to its anticonvulsant action in 6 days.

Physicians should use hypnotic agents appropriately and be aware of the reduced potential for producing tolerance and dependence with the nonbenzodiazepine hypnotic agents.

Weekly dosing produced tolerance to nicotine's decreasing effects on vertical activity and increases (i.e., sensitization) in horizontal activity at all doses, and these effects persisted for at least 3 weeks.

Repeated doses produced tolerance.

Interestingly, CB2 agonists can reduce nociception in several preclinical models of pain without producing tolerance [9] or central side-effects [11].