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The high percentage (61%) of radiosensitive cases found in our study with the LDR MN assay may point to the importance of defects in genes involved in the processing of radiation damage induced in G0 lymphocytes in breast cancer patients with a known or putative genetic predisposition.
These findings support the view that enhanced chromosomal radiosensitivity observed with the G2 and G0-MN assay in lymphocytes of a high proportion of breast cancer patients, cannot be due to a highly penetrant mutation in one gene, but may be due to low penetrance mutations in different genes involved in the processing of radiation induced DNA damage in G0 and G2 phase of the cell cycle.
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However, analyzing the formation and removal of γH2AX-foci in the different stem and progenitor cells (CD34+CD38−, CD34+CD38+ and CD34− subpopulations) we observed no differences in the induction and repair kinetics, suggesting that potential differences in their chromatin organization seem to have no impact on sensing and processing of radiation-induced DNA damage.
Since these calculations are performed in post-processing, the effects of radiation forces acting on the plasma during its magnetohydrodynamical evolution are not included.
Thus, dysfunction of genes and their protein products involved in the recognition and processing of the cellular radiation damage could be a possible molecular basis underlying the adverse radiotoxic reactions in healthy tissue.
Food irradiation – processing of food by ionizing radiation – is a safe, wholesome, efficient, reliable, and trustworthy technology to enhance the hygienic quality, to satisfy quarantine (for insects) requirements, to effect product improvements, and to achieve changes in technological properties.
Processing runs the risk of radiation leaks, — a small leak was one reason the last American mine was unable to renew its operating license and closed in 2002 — and disposing of the radioactive thorium is difficult and costly.
Radiation is to be more environmental friendly under transfer of radiation processing application to developing countries.
There are few areas which are important for future development of radiation processing applications: pollutants removal from gaseous and liquid waste, new products and new processes.
The dark material itself may have formed as a result of radiation processing of methane clathrates or radiation darkening of other organic compounds.
Borrely et al. (1998) have described that radiation processing refers to the use of radiation to change the properties of materials on an industrial scale and when radiation passes through materials it breaks chemical bonds.
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