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Ribosomal biogenesis requires both Pol I driven transcription and the efficient processing of nascent rRNA transcripts — 2 processes that have been shown to be regulated by PARP-1.
A new technique, high-velocity compaction (HVC), allows the processing of nascent semicrystalline polymer powders via sintering.
The development of a novel method for the processing of nascent UHMWPE leading to high ductility and strength extrudates is described.
Another study shows that during S phase of the cell cycle, RNAi-dependent processing of nascent heterochromatin transcripts promotes degradation of these transcripts and releases RNAPII from heterochromatin (Zaratiegui et al., 2011).
By coordinating activities of protein folding/modifying enzymes and interactions of molecular chaperones, ER optimizes the microenvironment for posttranslational processing of nascent proteins.
DOI: http://dx.doi.org/10.7554/eLife.03939.002 Co-transcriptional processing of nascent pre-mRNA is a central mechanism for gene regulation in eukaryotes and requires temporal coordination between transcription initiation, elongation, splicing, and cleavage.
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Lower molecular weight proteins, recognized by some affinity-purified antibodies, could be due to the proteolytic processing of the nascent protein as known in the case of MSP3.2 [30], or degradation products.
Most of the lower molecular weight molecules are the result of extracellular enzymatic processing of these nascent amelogenins.
We also describe the confirmatory cloning and sequencing of the dermcidin cDNA from the PIF peptide sequence and the investigation of co-translational processing of the nascent polypeptide in an in vitro translation system.
To gain a more complete understanding of the Pol II transcription cycle and how this is coordinated with co-transcriptional pre-mRNA processing, genome-wide analysis of nascent RNA has been undertaken.
The existence and dynamic behavior of side tunnels suggest that ribosomal proteins L4 and L22 might be involved in the regulation of a multiple exit system facilitating cotranslational processing (or folding or directing) of nascent proteins.
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