Thirdly, an acquired pri-miRNA processing deficiency might contribute to leukemogenesis by diminishing the production of mature miRNAs.
Only for the tRNAHis-flanked tRNASer AGY) a direct processing deficiency was observed in PNPase knockout cells [95].
To investigate whether the presumed processing deficiency also affected endogenous miR-221/222, qRT-PCR was performed on a panel of human myeloid cell lines.
Previous studies involving dyslexic subjects in comparison to controls have investigated hypotheses relating information processing deficiency with patterns of N100 component using ERP methodology.
As explanations for the elevated pri-miR-221/222 levels present in AML, pathologically increased transcription on the background of a physiologically limited processing capacity, or an acquired processing deficiency on the background of unaltered transcriptional activity may be considered.
In S. cerevisiae, these alterations consist of cold-sensitive splicing defects, growth delay at low temperatures, loss of nucleolar structural organization, pre-rRNA processing deficiency, and meiotic failure after aberrant splicing of key regulators [ 29, 31, 35].
Children and adolescents with LD often have a limited vocabulary, slower processing speeds, deficiencies in memory and communication, and may have difficulties reading social cues and avoid novel social situations [ 22, 23].
Peripheral blood natural killer (NK) cells from patients with transporter associated with antigen processing (TAP) deficiency are hyporesponsive.
Noncompliant food and environmental swab test results and noncompliant observations during inspections have led to both product recalls and incremental improvements in dairy processing plants when deficiencies noted on inspections are addressed (unpublished data).
