In addition, the biological relevance of the maturation process, as it affects hormone processing and secretion, remains to be determined in light of the differences between endocrine and neuroendocrine granules.
As expected, many of the functional categories that are involved in essential housekeeping functions, such as DNA and RNA metabolism, protein processing and secretion, cell structure, cellular processes, and energetic and intermediary metabolism, are represented in the core gene set.
Because the autocatalysis is mandatory for furin processing and secretion, the inert D153N was efficiently synthesized but inefficiently processed and secreted.
The mature pheromone is generated by the processing and secretion of the precursor protein ComX by ComQ.
On the one hand, ZnT8 is essential for insulin processing and secretion in response to glucose challenge thus total loss of its function causes glucose-intolerance.
We further show that proper processing and secretion were restored by over-expressing human signal receptor protein SRP14 and other components of the secretion pathway.
Therefore, our work indicates that the formation of an intramolecular disulfide bridge is necessary for normal processing and secretion of leptin.
Heat shock protein-47 (Hsp-47) is exclusive collagen specific molecular chaperone involved in the maturation, processing and secretion of procollagen.
Mutant mice with a targeted beta cell ZnT8 deficiency display glucose-intolerance, reduced beta cell zinc accumulation and increased proinsulin levels when fed with high-fat diet, indicating the deficiency in insulin processing and secretion.
Apart from distinct roles of inflammasomes in cancer mentioned above, inflammasome-mediated processing and secretion of IL-1β and IL-18 is critical in both innate and adaptive immune responses.
Autophagy plays critical roles in inflammation through influencing the development, homeostasis and survival of inflammatory cells, including macrophages, neutrophils and lymphocytes; effecting the transcription, processing and secretion of a number of cytokines, as well as being regulated by cytokines.
