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The promoters with ETS⇔CRE, obtained from the commonly bound regions by CREB and GABPα, are significantly enriched for the GO terms of proteolysis involved in macromolecule catabolic process, RNA processing, and cellular response to stress (Table 4).
Among the 338 pathways, 148, 31, 20 and 18 KEGG pathways were related with metabolism, environmental information processing, genetic information processing and cellular process, respectively.
We focused on the KEGG biochemical pathway database containing metabolic pathways, pathways related to genetic information processing, regulatory pathways involved in environmental information processing and cellular processes, and pathways active in human diseases and drug development.
The manually drawn and annotated pathway maps represent knowledge about the metabolism, genetic information processing, and cellular processes.
The top level consists of the following categories: metabolism, genetic information processing, environmental information processing, and cellular processes.
The results page of KEGG pathway details displays KEGG BRITE (metabolism, genetic information processing, environmental information processing and cellular process).
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The categories of metabolism, genetic information processing (GIP), environmental information processing (EIP), and cellular process involved 64.1%, 20.7%, 6.1%, and 9.1% of the total annotated unigenes, respectively.
Eukaryotic cells possess a complex network of RNA machineries which function in RNA-processing and cellular regulation which includes transcription, translation, silencing, editing and epigenetic control.
In addition to metabolism pathways, genes involved in genetic information processing (6,781) and cellular processes (1,718) were highly represented categories.
Several gene families that function in regulation of information storage and processing, metabolism and cellular processes and signaling are seen to be expanded in specific lineages.
The up- and down-regulated genes were mainly annotated with the GO terms, genetic information processing, metabolism, and cellular processes and 16 unigenes were annotated with the GO term immune-related (Table 8).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com