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One reason may be that the treatments have been non-specific and have not targeted the processes shown to be associated with poor recovery, such as post-traumatic stress symptoms.
This is especially plausible as Gene ontology analysis of the predicted targets of mir-21 suggest it should inhibit genes involved in ubiquitin ligase and JAK-STAT activity, both which were processes shown to be significantly up regulated in the transcriptomes of the patients.
As "axon guidance" was one of the processes shown to be significantly overrepresented in REGGED, we focused in the further course of the study on genes involved in axon guidance, a process that has not been previously described in the glomerulus of healthy human adult kidneys.
Alternatively, this pattern might also be an effect of recombination and gene conversion, processes shown to be frequent in passerine Mhc systems [ 20, 23].
By designing experiments to explore processes shown to lack functional coverage and by leveraging all available data to interpret new results, laboratory work can be quickly guided to areas of biological interest and potential.
The review focused on evidence-based care processes shown to increase the likelihood of achieving the best possible clinical outcomes, following the criteria proposed by Saslow et al. [ 17].
Similar(51)
In fact, neither the elimination therapies nor the treatments directed to counteract the inflammatory processes showed to be efficacious in reverting PQ-related pathophysiological alterations.
To compute an optimal query assignment policy, a Discrete Time Markov Decision Process, shown to be stochastically equivalent to the initial continuous time process, is formulated.
Civil rights groups are suing Indiana officials to block the state from purging voters from its rolls using a process shown to inaccurately identify voters registered in multiple states.
Mutant p53 was also demonstrated to inhibit autophagy (113), a process shown to modulate breast tumor formation and development (114).
Progressive fatty degeneration of hepatocytes is associated with oxidative stress and subsequent hepatocyte damage, a process shown to contribute to tumorigenesis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com