In the past, making the necessary modifications could require synthesizing the entire molecule from scratch, often a difficult process requiring multiple steps.
It is often an iterative process requiring multiple modeling frameworks to understand different aspects of the flow problem.
We note that the optimization design process requires multiple design loops involving similar or even repeated computations at the microscopic scale, which potentially suits the surrogate learning process.
Based on results from this model, we hypothesize, due to the considerable degeneracy in the T cell repertoire, that induction of full-blown autoimmune disease via molecular mimicry is a tightly regulated process requiring multiple factors related to the pathogen expressing the potential mimic epitope.
The process requires multiple, painful sessions, and even then might only deliver a marginal improvement.
In a 10½ hour operation, doctors removed Susan's vagina, uterus and lymph nodes -- reconstructing her vagina with her colon, a process requiring multiple major surgeries over the next three years.
Before we get to the actual nuts and bolts of voting, you should know that depending on where you live voting may be an annoying process requiring multiple trips to government offices, the post office, or a polling place, and you'll probably have to do it on weekdays when you're going to school.
Although secretion of α-toxin by internalized bacteria has been shown to kill host cells [18], [30] it is becoming increasingly apparent that other signals from internalized, metabolically active staphylococci are required to induce apoptosis and that this process requires multiple virulence factors [29], [31] [33].
Filovirus entry is a complicated process requiring multiple endosomal components.
