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McDonald believes that a similar process of nerve regeneration is taking place inside Reeve's body.
Although later research showed the process of nerve and muscle stimulation to be much more complex than Du Bois-Reymond's model, the summation of his studies in Untersuchungen über thierische Elektricität, 2 vol. (1848 1884; "Researches on Animal Electricity"), created the field of scientific electrophysiology.
Acetylcholinesterase is a very rapid enzyme, essential in the process of nerve impulse transmission at cholinergic synapses.
After peripheral nerve injuries, the process of nerve regeneration and target reinnervation is very complex and depends on many different events occurring not only at the lesion site but also proximally and distally to it.
Neuregulin 1 (NRG1) is a multifunctional and versatile protein: its numerous isoforms can signal in a paracrine, autocrine, or juxtacrine manner, playing a fundamental role during the development of the peripheral nervous system and during the process of nerve repair, suggesting that the treatment with NRG1 could improve functional outcome following injury.
Nerve growth factors (neurotrophins) are molecules that are naturally released in the process of nerve regeneration.
Therefore, neurotrophic factors have been extensively investigated in animal models of nerve injury to further enhance and accelerate the process of nerve regeneration and functional recovery [ 5].
This feature will reflect a more diffuse neurological injury or an impaired process of nerve recovery affecting phrenic nerves as well.
The reduction of substance P content in skin after topical capsaicin administration is thus consequent to this process of nerve fibre defunctionalization and retraction.
It represents a progressive, diffuse, and length-dependent process of nerve injury, involving factors other than simple exposure to hyperglycemia (1).
Comparison to mice, 6 weeks following nerve transection in which regeneration is totally blocked, would be helpful for perspective and to judge the relative impact of satellite cell depletion on the process of nerve regeneration.
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