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Thus our results suggested that the lack of Hsf4 up-regulated the expression of Ubc, which might be involved in the development of cataract by regulating the cellular processes of lens.
These miRNAs were implicated in neuronal differentiation and, given multiple similarities between lens and neuronal differentiation (Frederikse et al. 2012), future studies of these miRNAs will shed new light into the miRNA-dependent processes of lens fiber cell and neuronal differentiation.
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Fiber cells could no longer be observed indicating abnormalities in the differentiation process of lens cells (Fig. 1, i p).
This represents the normal process of lens development as well.
Our studies show that expression of both Bit1 and PKD is modulated during the process of lens denucleation.
This paper reports for the first time a molecular study of the entire process of lens development, from the establishment of the lens placode to adulthood, in a species of subterranean mammals, the Iberian mole.
These results provide new molecular insights into the process of lens fiber terminal differentiation and open new research avenues to probe chromatin structure prior to and during lens fiber cell denucleation.
Finally, it is also possible that SWI/SNF complexes containing Brg1 participate in the process of lens fiber denucleation independently through controlling local chromatin structure in those regions that exhibit initial DNA damage.
In this paper we have studied the whole process of lens differentiation in the Iberian mole (Talpa occidentalis, Cabrera 1907), in order to determine whether the eye defects of these subterranean insectivores are a consequence of a degenerated or a developmentally retarded visual system.
The natural ageing process of the lens leads to increased lens yellowing [ 24] and the aged lens contains UV-absorbers and chromophores that absorb both ultraviolet radiation [ 22, 25] and with age increasing proportions of violet, blue and to a lesser extent green light too [ 26].
Basic hydrogeological and hydrochemical knowledge regarding the recharge and salinisation processes of freshwater lenses is important to ensure sustainable utilisation, especially considering possible climate change effects.
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