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It has also been suggested that oxidative stress, which may induce protein modifications altering their activity or function, may accelerate the basic pathogenic processes of diabetic complications [5], [6], [7].
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Advanced glycation end products (AGEs) trigger an oxidative reaction which then accelerates endothelial cell apoptosis; this is a critical event in the process of diabetic vascular complications.
We assumed that Fibrinogen-like protein 2 (Fgl2) plays an important role during the process of diabetic cardiomyopathy (DCM).
So it allowed us to assume that Fgl2 plays an important role during the process of diabetic cardiomyopathy (DCM).
This study highlights the improvements in the process of diabetic care that have been achieved in primary care without the inducements of national targets.
In this design, GPs are "units of measure" of the process of diabetic care delivery, as they manage laboratory and preventive care for most patients with type 2 DM.
In our design, GPs were "units of measure" (clusters) of the process of diabetic care delivery, as they managed laboratory and preventive care for most patients with type 2 DM.
Trends in recording of measurements linked to the process of diabetic care where targets are set in NICE guidance are shown in Figure 3. Recording of all measures has increased (P < 0.001), especially the recording of HbA1c (practice median 34%% in 1994 to 74% in 2001) and cholesterol (practice median 17% in 1994, 61% in 2001).
Our study is unique in that it included the quality indicators of preventive care processes for diabetic complications and diabetes-related clinical outcomes comprehensively.
The healing process of the diabetic foot took a favourable turn.
In conclusion, we have performed the first longitudinal study describing the kinetics of expression of MMPs during the healing process of chronic diabetic foot ulcers.
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