Combined, these two processes can result in the emergence of a stable disease state (Figure 8).
Here, we give a detailed treatment of the role of evolutionary processes in the emergence and maintenance of functional modules in signaling pathways.
The identification of potential drug targets in heart failure should include integrative approaches to estimate significant roles of genes in regulatory processes driving the emergence of heart failure.
Lineage mixing enables distantly related pathogen strains to outbreed, and this process can result in the emergence of novel, virulent genotypes that spread rapidly through susceptible host populations, as appears to have occurred with chytridiomycosis (9 ).
Given the involvement of ERK and DARPP-32 in LIDs, as indicated by studies performed in rodent models [5], [6], [7], these results are compatible with the hypothesis that coordinated activation of cAMP/PKA/DARPP-32 and ERK is implicated in the priming processes underlying the emergence of dyskinesia.
We explicate this perspective through a comparative study of processes underlying the emergence of wind turbines in Denmark and in United States.
Thus, the evolutionary processes underlying the emergence of extreme resistance in Deinococci appear not to be dependent on a particular set of genes for sugar- or nitrogen-metabolism.
This feeling implies the involvement of subconscious processes against conscious awareness in the emergence of the odd sensation.
The most abundant methyltransferase in human cells is protein arginine methyltransferase 1. Methylation processes appear to interfere in the emergence of several diseases, including cancer.
The acquisition of extracellular proteins with structural roles, a highly regulated extracellular protease cascade, and additional regulatory genes allowed early actinobacterial stationary phase processes to be redeployed in the emergence of aerial hyphae from mycelial mats and in the formation of spore chains.
