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Most of the pathways enriched in M1 are directly related to biological processes in asthma, including 'Asthma', 'Cell adhesion molecules (CAMs ', 'Antigen processing and presentation', 'Cytokine-cytokine receptor interaction', 'Toll-like receptor signaling pathway'PPARPAR signaling pathway', 'Leukocyte transendothelial migration' and 'Chemokine signaling pathway'.
The protein modifications occur not only as a result of endogenous inflammatory processes in asthma but also from inhalation of exogenous environmental oxidants.
Our findings suggest an isoform-specific link to pathogenetic processes in asthma and allergy.
DNA sequence variants in the GSTP1 locus may contribute to susceptibility to oxidative stress and airway inflammation, which are key processes in asthma pathogenesis.
Associations of α-tryptase copy number with serum IgE levels, atopy scores and bronchial function may reflect roles for tryptases in regulating IgE production and other processes in asthma.
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Hyaluronic acid is also important in regulating the remodelling process in asthma.
In animal studies, sex influences the remodeling process in asthma [ 21, 22], and possible reasons need to be further explored.
Previously we reported findings consistent with CXCL10 being a key regulator of this process in asthma (5).
The inflammatory process in asthma is considered to be driven in part by cytokines derived from Th2 lymphocytes recruited into the airway.
Activated Th2 cells produce various cytokines, including interleukin (IL -4, IL -4 and IL-53, which induce andivation and recruitment of inflammatory cells, and overproduction of mucus, during the inflammatory process in asthma.
Collectively, these 7 selected miRNAs are expected to participate in the regulation of several biological processes involved in asthma as illustrated in Figure 3.
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