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The conservation of RORs across species underlies the importance of the ROR family through a number of processes during evolution.
Our results help clarify the respective roles of these two processes during evolution and add new layers to the current understanding of mammalian genome evolution.
Dermo-epidermal interactions and differential cell growth and cell death processes in the adjacent layers of the feather follicle established the first feathers which gained complexity by the fine-tuning of epithelial growth and fusion processes during evolution [ 29, 32].
It is curious to find similar rearrangement rates among non-mammalian vertebrates that differ so greatly in life history and genome structure, and whose genomes have been shaped differently by lineage-specific processes during evolution.
19– 21 The occurrence of class I (which detects water-borne odors) and class II (which detects air-borne odors) types of ORs could be a result of adaptive processes during evolution and are also observed in higher eukaryotes including humans.
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In order to enhance the convergence process during evolution, the integer based representation scheme and corresponding genetic operators are well designed with appropriate constraint control mechanisms.
Moreover, the ARF pattern from these genes had only one cluster of ARFs (shorter than ∼750 bases), indicating that the longer non-conforming ORFs must have been derived due to a specific biological process during evolution.
Contrary to previously introduced substituional models based on an the assumption that all sites of the protein undergoes the same substitution process during evolution, the Bayesian mixture CAT model allows to describe distinct substitution processes at the amino-acid replacement occurring in different sites of a protein alignment [26].
Such a process during evolution ensures both stability and low energy consumption in an efficient protein-protein interaction.
This implies that the specificity of the clade II enzyme was changed in a gradual process during evolution after the duplication.
The observation that some imprinted domains in mouse and human are not imprinted in marsupials, suggests that imprinting was a step wise process during evolution beginning after the evolution of viviparity and continuing convergently in the marsupial and eutherian lineages.
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