Further, if there are definable subsets of people with a distinct neuropathological profile even within a DSM-defined illness (e.g., see [ 13]), then it would follow that identifying a single biomarker test that reflects the underlying disease processes with a high degree of diagnostic sensitivity and specificity should be unlikely.
To describe all intra- and extracellular processes associated with a disease and integrate heterogeneous sets of experimental data, a Quantitative Systems Pharmacology (QSP) modeling approach can be employed.
Still, one can say that biomarkers reflect biological processes associated with a disease, making them more interesting for personalized medicine rather than for a statistical point of view.
When significant changes happen, though, these changes become associated with a disease process and people get scared.
Patients with brain cancer are afflicted with a disease process that is able to escape local therapy.
By considering how the system changes with a disease process or a proposed treatment, quantitative understanding of an intervention becomes possible.
Secondary database curators could implement it in order to find additional genes associated with a disease process, as recorded in bibliographic text.
It is reasonable to argue that metabolomics is typically more closely associated with a disease process or drug effect than proteins, mRNA, or genes [ 46].
The dynamic and interactive properties of blood give rise to the possibility that subtle changes occurring within the body, such as changes in association with a disease process or in response to an injury, may leave 'footprints' in blood.
Overall, the distribution and relative abundance of tau filaments in 5 cases were consistent with a disease process prominently affecting the frontal and temporal lobes of the cerebral cortex.
A recent study showed the implication of SOST, a potent inhibitor of canonic Wnt signaling by binding to LRP5/6 in OA disease processes with opposing effects by promoting disease-associated subchondral bone sclerosis and inhibiting degradation of cartilage [ 20].
