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In normal hearing, sound is processed in the cochlea, a tube that is curled in a spiral like a nautilus shell and contains the organs of hearing.
Puel believes that glutamate, a neurotransmitter, is inappropriately processed in the cochlea, which causes abnormal impulses from the acoustic nerve, and that by infusing the animal's ear with a drug that blocks the action of glutamate he can reduce the tinnitus.
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The simple feed-forward mechanism is able to capture the properties of the noncausal active process in the cochlea without a second filter or resonance.
The invariance group for the hearing process in the cochlea is thus the product Γ × S of the affine group Γ with the circle group S. Signal processing in the cochlea is highly compressive and thus non-linear.
More specifically, Lyon found that active processes in the cochlea could be modeled by tuning each section to have a small resonant frequency band, in which the gain from input to output is slightly larger than unity.
Therefore, our findings identified one important pathogenic process in the cochlea of the mutant mice.
This study provides the first direct experimental evidence showing that the transfer of metabolically-important molecules in cochlear supporting cells is dependent on the normal function of GJs, thereby suggesting a novel pathogenesis process in the cochlea for Cx-mutation-linked deafness.
This is in line with our knowledge of the timing of developmental maturation processes in the cochlea and auditory nerve.
This remarkable performance depends on mechanical and biophysical processes in the cochlea and the peripheral organ of hearing.
The idea of active processes in the cochlea was first raised by Gold [ 6] and evidenced by Kemp [ 7] in the form of objective tinnitus and otoacoustic emissions.
In this study, we show that ROS trigger the inflammatory process in the cochlea by activating signal transducer and activator of transcription-1 (STAT1).
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