Expression patterns of cell type-specific miRNAs could partially reflect the characteristics of K562, HL-60 and THP-1 cell lines, such as actin filament-based processes, responsiveness to stimulus and phagocytic activity.
Process-responsiveness is suggested for identifying situations that require stakeholder involvement specifically during R&D.
Takes actions to open-up the innovation to stakeholder engagement during R&D, when process-responsiveness alerts of such need.
Process-responsiveness is suggested for identifying situations, which particularly require opening-up of the innovation at R&D level.
This section suggests process-responsiveness, product-responsiveness, and presponsiveness as further elaborations for the concept of responsiveness (See Fig. 1).
Product-responsive innovation: Takes actions to open-up the innovation to stakeholder engagement during R&D, when process-responsiveness alerts of such need.
Process-responsiveness also makes RRI more explicit about what is expected of company innovators, if they are to become mutually responsive with societal actors with a view to the societal aspects of the innovation (von Schomberg, 2013).
To recap: While our suggestion for process-responsiveness stemmed from the challenge that opening-up does not often occur at the R&D level, three further challenges regarding mutual responsiveness appear where such opening-up is (allegedly) ensued.
Inspired by limitations of mutual responsiveness, we first propose process-responsiveness: an elaboration of responsiveness as the action-element of RRI that triggers attention to societal uncertainties, which particularly call for R&D-level opening-up.
As we discussed over process-responsiveness, ambiguous uncertainty indicates a need for opening-up the innovation at the R&D-level to the deliberation on goals and purposes, which based on RRI's ideas should involve both innovators and stakeholders.
In summary: With process-responsiveness, we suggest to consider the extent of uncertainty in weighing whether to open-up the innovation at (procedural) R&D level to joint societal reflections, and to communicate these uncertainties across the organisation.
