The physiological significance of this process is underscored by analysis of chaperone activity in the presence of non-native SNAP25 and VAMP2, which activated only CHL1/Hsc70/αSGT and CHL1/CSP complexes, respectively, but not the Hsc70/CSP/αSGT complex.
However, UNHCR reckons the number may be underreported given limitations of the interview process, underscoring that the decision to migrate is based on multiple factors.
The large number of different E2 and E3 enzymes and DUBs identified to date and their involvement in a great variety of processes underscores the complexity of regulation by ubiquitylation [ 91].
Furthermore, our recent studies demonstrated that a loss of ADA3 induces genomic instability and delay in DNA repair process [ 39], underscoring the role of ADA3 in oncogenesis.
For Mr. Feinberg, the process of cutting pay underscored the widening divide between Wall Street and the rest of America, where even a fraction of a banker's pay seems like riches to many people.
The significance of this process is underscored by the association of mutations in microtubule motor proteins and their co-factors with several neurological disorders (Hirokawa et al., 2010; Schiavo et al., 2013).
The significance of the process is underscored by observations that even relatively small perturbations to the assembly process, such as mutations in nonessential components of the BAM complex, compromises the barrier function of the outer membrane leaving mutant bacteria hypersensitive to antibiotics.
The voices of APEs are key in this process and underscore the importance of continued communication between the health system and communities [ 35, 36].
This finding stresses that health-care seeking is a complex process and underscores the importance of broadening the field of inquiry.
In this process, workers underscored the facets of their jobs that might serve as evidence of status, while they simultaneously highlighted the undesirable elements of jobs that social others performed, not only concealing the full range of duties each group enacted but also masking common tasks.
DDX21 knockdown primarily inhibited rRNA processing at the initial 47S processing step and did not result in the accumulation of other downstream intermediates that were not processed properly, again underscoring the role of DDX21 in the first step 47S rRNA processing.
