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The recombination-activating genes (RAGs) encode for V(D J recombinases responsible for rearrangements of antigen-receptor genes during T and B cell development, and RAG expression is known to correlate strictly with the process of rearrangement.
While this dataset [36] was also generated by PCR, the incorrectly-processed molecules were in greater abundance (permitting PCR cycle number to be small), because the process of rearrangement had been experimentally stalled or halted by depleting specific RNA templates for two independent genes via RNAi.
Gene BCR is central in this study, because it is involved in the process of rearrangement.
(In that sense, BP* and BP attempt to shape the noise by returning to the underlying evolutionary process of rearrangement or mutation).
We believe that the proposal of a massive WGD in the yeast lineage based solely on the evidence of interleaving patterns in sister regions (i.e., DS) is unwarranted and that DS events are more likely a natural topological consequence of a more gradual process of rearrangement within and between chromosomes.
It is particularly unusual to find this in a mitochondrial genome that has not undergone significant rearrangements, since intergenic non-coding regions appear in some cases to be vestiges of pseudogenes generated by the gene duplication-random loss process of rearrangement [ 12, 16, 17, 31].
Similar(53)
Most cells in the adult thymus express the co-receptor molecules CD4 and CD8 and represent an intermediate stage in αβ T cell development that has undergone productive TCRβ rearrangement and is in the process of TCRα rearrangement.
It is not created by some arcane process of molecular rearrangement.
Thus, the process of mass rearrangement at a/c interface lags behind in set B samples as compared to set A samples.
Fusion inhibitors of HIV prevent the virus from entering into the target cell via the interaction with gp41, which stops the process of spatial rearrangement of the viral envelope protein.
During megakaryocyte maturation, the polyploid cell undergoes a complex process of cytoskeletal rearrangement, followed by proplatelet elongation, and the release of cytoplasmic fragments as circulating platelets [27].
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