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Pluripotent cells arise within the inner cell mass (ICM) of mammals and have the potential to generate all cell types of the adult organism through a process of commitment and ordered differentiation.
The process of commitment to the neurogenic lineage is directed by a cascade of antagonistic basic – helix – loop – helix (bHLH) genes evolving around the Delta1/Notch1 signalling pathway.
The analysis also revealed significant heterogeneity of molecular programs throughout the process of commitment.
Their results will force those studying the process of commitment to cell division to revisit old data and will initiate new investigations, kicking off an exciting rebirth of a well-established field.
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The process of personal commitment, exploration, loss, surprise and puzzlement fluctuates and coheres.
The researchers suggested that this represents a process of "neural commitment," in which the infant brain wires itself to understand one language and its sounds.
This result suggested that these atypical progenitors had relatively normal VDJ recombination of TCR Vβ, that the severe TEC defect in the Foxn1Δ/Δ thymus did not significantly affect the ability to support the process of TCRαβ commitment, and that there was no selective loss of specific Vβ bearing clones during positive selection.
For genes that act in the process of lineage commitment this distinction is often blurred.
It would therefore be interesting to study the process of adipocyte commitment in the context of a vascular reporter line such as fli1 EGFP.
Collectively, these findings provide new insights into how oncogenic mutations might subvert the normal process of lineage commitment and dictate the phenotype of resulting malignancies.
Analyses of the gene expression data and promoter sequences produced a set of 65 genes that are candidates for genes involved in the process of adipocyte/osteoblast commitment.
More suggestions(15)
process of compromise
process of investment
process of assurance
process of intention
process of leadership
process of orientation
process of willingness
process of appointment
process of allocation
process of affirmation
decision of commitment
examination of commitment
process of desire
process of involvement
process of undertaking
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CEO of Professional Science Editing for Scientists @ prosciediting.com