Exact(5)
All 3 antagonists induced significant decreases in process dynamism, with NBQX inducing the largest decrease in motility (NBQX: −27.1%, GYKI: −12.1%, and APV: −12.5%) (Fig 2E).
Process dynamism also enables microglia to make direct and repeated physical contact with surrounding cells without having to migrate or physically translocate their cell bodies.
As rapid and constitutive process dynamism entail energetic and metabolic expenditures, it is probably advantageous for it to be regulated according to the changing needs of the neural parenchyma.
These results indicate that endogenous ionotropic glutamatergic transmission occurring through both AMPA and kainate receptors, and, to a smaller extent, NMDA receptors, positively regulate microglial dendritic structure and process dynamism.
Inasmuch as microglial process dynamism is thought to provide synapse maintenance [8], [40] and to deliver trophic factors to neurons [9], it would be consistent to hypothesize that signaling mechanisms that reflect neuronal activity would be well suited to regulate microglial morphology and behavior in this regard.
Similar(53)
The modern economic and political order in Central and Eastern Europe has served to increase the process of urban dynamism in the city.
Music is closer to the inner dynamism of process; there are fewer technical (and no concrete) impediments to immediate apprehension, for an entire dimension of the empirical world has been bypassed.
Disability has been found to be a dynamic process over short periods of time and we have shown that this dynamism relaxes long term to form distinct trajectories.
Implementation must be considered to be a planned process whose main characteristics are dynamism and uniqueness [ 6].
Life is by definition dynamic, and this dynamism is key to understanding the mechanisms between cause and effect for biological processes.
Although termed "resting", microglia in the retina and the brain exhibit rapid and extensive dynamism in their processes, enabling each microglial cell to come into close proximity and establish repeated contact with nearby neurons, macroglia, and blood vessels [1], [2], [3].
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