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Processing hPSCs in this manner can help to avoid process bottlenecks and increase throughputs of hPSC product manufacture.
Hence, we need process intensification (PI) technologies to drastically improve chemical production processes and to overcome the most difficult process bottlenecks.
It is very important to develop effective strategies for process industry to implement feasible scheduling while the process bottlenecks work optimally.
Retrofit projects target overcoming process bottlenecks, yet many of them such as heat and mass transfer or reaction equilibrium limitations cannot be tackled within classical chemical engineering approaches.
Starting with a base-case design, the process flow sheets for the three routes are studied in detail to identify the process bottlenecks or hot-spots.
Additionally, some stages (particularly cooling) were slow and inefficient, creating significant production process bottlenecks.
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As expected, the process bottleneck is the reactive distillation unit and, in particular, the control strategy to achieve coupled targets.
In particular, the rheological analysis allowed a more realistic estimation of energy demands for heat transfer and agitation in the hydrolysis stage, which resulted to be the process bottleneck and determined the cycle time and, consequently, defined the equipment size.
One of the reasons for this reluctance is the lack of suitable retrofitting methodologies enabling both identifying the most promising PI option for a given process bottleneck and evaluating possible improvements through the implementation of this technology.
Hence, improved fundamental understanding of the inhibitory mechanism selectively targets xylose fermentations could help alleviate this crucial process bottleneck.
KED and AS-K were responsible for the overall coordination of the country consultation process, bottleneck analysis tool development, data analysis and reviews of the paper drafts.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com